Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer.

PURPOSE: There is an unmet need for biomarkers for identifying patients likely to benefit from anticancer treatments, selecting dose, and understanding mechanisms of resistance. Plasma vascular endothelial growth factor (VEGF) and soluble VEGF receptor 2 (sVEGFR-2) are known to be modulated by VEGF...

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Bibliographic Details
Main Authors: Hanrahan, E, Lin, H, Kim, E, Yan, S, Du, D, McKee, K, Tran, H, Lee, J, Ryan, A, Langmuir, P, Johnson, B, Heymach, J
Format: Journal article
Language:English
Published: 2010