Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

OBJECTIVE: Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes. We describe the effects of d...

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Bibliografiske detaljer
Main Authors: Nicolson, T, Bellomo, E, Wijesekara, N, Loder, M, Baldwin, J, Gyulkhandanyan, A, Koshkin, V, Tarasov, A, Carzaniga, R, Kronenberger, K, Taneja, T, da Silva Xavier, G, Libert, S, Froguel, P, Scharfmann, R, Stetsyuk, V, Ravassard, P, Parker, H, Gribble, F, Reimann, F, Sladek, R, Hughes, S, Johnson, P, Masseboeuf, M, Burcelin, R
Format: Journal article
Sprog:English
Udgivet: 2009

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