Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.

During biosynthesis of the clinically used beta-lactamase inhibitor clavulanic acid, one of the three steps catalysed by clavaminic acid synthase is separated from the other two by a step catalysed by proclavaminic acid amidino hydrolase (PAH), in which the guanidino group of an intermediate is hydr...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Elkins, J, Clifton, I, Hernández, H, Doan, L, Robinson, C, Schofield, C, Hewitson, K
Natura:	Journal article
Lingua:	English
Pubblicazione:	2002

Documenti analoghi

Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.
di: Caines, M, et al.
Pubblicazione: (2004)

Studies on an N-terminal nucleophile hydrolase and enzymes of clavulanic acid biosynthesis
di: Iqbal, A
Pubblicazione: (2008)

Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid.
di: MacKenzie, A, et al.
Pubblicazione: (2007)

Chemistry and biosynthesis of clavulanic acid and other clavams.
di: Baggaley, K, et al.
Pubblicazione: (1997)

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.
di: Elkins, J, et al.
Pubblicazione: (2005)

ISOLATION OF AN INTERMEDIATE IN CLAVULANIC ACID BIOSYNTHESIS
di: Baldwin, J, et al.
Pubblicazione: (1990)

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.
di: Iqbal, A, et al.
Pubblicazione: (2010)

ISOLATION OF DIHYDROCLAVAMINIC ACID, AN INTERMEDIATE IN THE BIOSYNTHESIS OF CLAVULANIC ACID
di: Baldwin, J, et al.
Pubblicazione: (1991)

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.
di: Arulanantham, H, et al.
Pubblicazione: (2006)

EXPRESSION IN ESCHERICHIA-COLI OF A CLAVAMINIC ACID SYNTHASE ISOZYME - A TRIFUNCTIONAL OXYGENASE INVOLVED IN CLAVULANIC ACID BIOSYNTHESIS
di: Lawlor, E, et al.
Pubblicazione: (1994)

The origin of the beta-lactam carbons of clavulanic acid
di: Thirkettle, J, et al.
Pubblicazione: (1997)

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.
di: Kershaw, N, et al.
Pubblicazione: (2002)

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.
di: Valegård, K, et al.
Pubblicazione: (2013)

Transgenic plant-produced hydrolytic enzymes and the potential of insect gut-derived hydrolases for biofuels
di: Jonathan eWillis, et al.
Pubblicazione: (2016-05-01)

Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives.
di: Brown, R, et al.
Pubblicazione: (1997)

Serotonin syndrome induced by amoxicillin–clavulanic acid
di: L. Naya Ríos, et al.
Pubblicazione: (2024-04-01)

Amoxycillin-clavulanic acid treatment of melioidosis.
di: Suputtamongkol, Y, et al.
Pubblicazione: (1991)

Clavulanic Acid Adsorption Studies in Zeolites
di: Marcus Bruno Soares Forte, et al.
Pubblicazione: (2011-05-01)

Overproduction of clavulanic acid by extractive fermentation
di: Cecília Ladeira Lopes Costa, et al.
Pubblicazione: (2015-05-01)

Bibliometric Analysis of Global Research on Clavulanic Acid
di: Howard Ramirez-Malule
Pubblicazione: (2018-11-01)

Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds
di: Coralie Carivenc, et al.
Pubblicazione: (2021-09-01)

Influence of gibberellic acid on hydrolytic enzymes activity in germinating different-aged lupin seeds
di: T. Mierzwińska
Pubblicazione: (2015-01-01)

The activity of amoxycillin/clavulanic acid against Pseudomonas pseudomallei.
di: Dance, D, et al.
Pubblicazione: (1989)

Amoxicillin/clavulanic acid-induced pancreatitis: case report
di: Sana Chams, et al.
Pubblicazione: (2018-08-01)

Clavulanic acid improves ethanol withdrawal symptoms in rats
di: Ehsan Mohebi, et al.
Pubblicazione: (2020-06-01)

Interplay of Isomorphs and Polymorphs of Amidino-Copper(II) Complexes with Different Halides
di: Zaina Yamba, et al.
Pubblicazione: (2024-03-01)

Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles
di: Livio Racané, et al.
Pubblicazione: (2021-01-01)

Streptomyces clavuligerus strain selection for clavulanic acid biosynthesis: a study based on culture composition effects and statistical analysis
di: Laura Pinilla, et al.
Pubblicazione: (2018-04-01)

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.
di: Brown, R, et al.
Pubblicazione: (1996)

THE COORDINATION COMPOUNDS OF COBALT (II, III) WITH DITHIOCARBAMIC ACID DERIVATIVES — MODIFICATORS OF HYDROLYTIC ENZYMES ACTIVITY
di: L. D. Varbanets, et al.
Pubblicazione: (2013-02-01)

Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
di: O'Connor Peter B, et al.
Pubblicazione: (2009-07-01)

Role of ursodeoxycholic acid in prevention of hepatotoxicity caused by amoxicillin-clavulanic acid in rats
di: Gamal A. El-Sherbiny, et al.
Pubblicazione: (2009-04-01)

Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid.
di: Mackenzie, A, et al.
Pubblicazione: (2010)

Enzyme-mediated hydrolytic activation of prodrugs
di: Yan-hui Yang, et al.
Pubblicazione: (2011-10-01)

Hydrolytic enzymes in spermatogenesis in Marchantia polymorpha
di: Alicja Górska-Brylass
Pubblicazione: (2015-01-01)

Production of clavulanic acid and cehphamycin C by Stretpmyces clavuligerus in palm oil medium
di: Lee, Ping Chin, et al.
Pubblicazione: (1996)

Rich Organic Nitrogen Impacts Clavulanic Acid Biosynthesis through the Arginine Metabolic Pathway in Streptomyces clavuligerus F613-1
di: Jiafang Fu, et al.
Pubblicazione: (2023-02-01)

In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus.
di: Santosh K Srivastava, et al.
Pubblicazione: (2019-01-01)

Focal destructive cholangiopathy associated with amoxycillin/clavulanic acid (Augmentin).
di: Ryley, N, et al.
Pubblicazione: (1995)

Production clavulanic acid from Streptomyces Clavuligerus through fermentation /
di: Mohd. Azmi Mat Zain, 1989-, author, et al.
Pubblicazione: (2012)