Mechanisms of transcriptional dysregulation in repeat expansion disorders.

Mechanisms of transcriptional dysregulation in repeat expansion disorders.

Approximately 40 human diseases are associated with expansion of repeat sequences. These expansions can reside within coding or non-coding parts of the genes, affecting the host gene function. The presence of such expansions results in the production of toxic RNA and/or protein or causes transcripti...

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Bibliografiske detaljer
Main Authors:	Groh, M, Silva, L, Gromak, N
Format:	Journal article
Sprog:	English
Udgivet:	2014

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