Kinase inhibitor selectivity profiling using differential scanning fluorimetry.

Fast, robust, and inexpensive screening methods are the heart of drug discovery processes. Moreover, it is useful to have access to several established assay formats, for validation purposes. If a targeted protein is an enzyme, the logical and widely used approach is the direct measurement of the ef...

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Bibliographic Details
Main Authors: Fedorov, O, Niesen, F, Knapp, S
Format: Journal article
Language:English
Published: 2012