A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens

Spatial omics is enabling unprecedented tissue characterization, but the ability to adequately compare spatial features across samples under different conditions is lacking. We propose a quantitative framework that catalogs significant, normalized, colocalizations between pairs of cell subpopulation...

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Bibliographic Details
Main Authors: Bouchard, G, Zhang, W, Ilerten, I, Li, I, Bhattacharya, A, Li, Y, Trope, W, Shrager, JB, Kuo, C, Ozawa, MG, Giaccia, AJ, Tian, L, Plevritis, SK
Format: Journal article
Language:English
Published: Nature Research 2025