Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.

AIMS/HYPOTHESIS: Proinflammatory cytokines contribute to beta cell destruction in type 1 diabetes, but the mechanisms are incompletely understood. The aim of the current study was to address the role of the protein kinase C (PKC) isoform PKCδ, a diverse regulator of cell death, in cytokine-stimulat...

पूर्ण विवरण

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मुख्य लेखकों: Cantley, J, Boslem, E, Laybutt, DR, Cordery, D, Pearson, G, Carpenter, L, Leitges, M, Biden, T
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2011