A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

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The jumonji (JMJ) family of histone demethylases are Fe2+- and α-ketoglutarate-dependent oxygenases that are essential components of regulatory transcriptional chromatin complexes. These enzymes demethylate lysine residues in histones in a methylation-state and sequence-specific context. Considerabl...

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Main Authors: Kruidenier, L, Chung, C, Cheng, Z, Liddle, J, Che, K, Joberty, G, Bantscheff, M, Bountra, C, Bridges, A, Diallo, H, Eberhard, D, Hutchinson, S, Jones, E, Katso, R, Leveridge, M, Mander, P, Mosley, J, Ramirez-Molina, C, Rowland, P, Schofield, C, Sheppard, R, Smith, J, Swales, C, Tanner, R, Thomas, P
格式: Journal article
语言:English
出版: 2012

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