Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA.
In addition to double- and single-strand DNA breaks and isolated base modifications, ionizing radiation induces clustered DNA damage, which contains two or more lesions closely spaced within about two helical turns on opposite DNA strands. Post-irradiation repair of single-base lesions is routinely...
| Päätekijät: | , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
2001
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| _version_ | 1826279468135612416 |
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| author | Dianov, G O'Neill, P Goodhead, D |
| author_facet | Dianov, G O'Neill, P Goodhead, D |
| author_sort | Dianov, G |
| collection | OXFORD |
| description | In addition to double- and single-strand DNA breaks and isolated base modifications, ionizing radiation induces clustered DNA damage, which contains two or more lesions closely spaced within about two helical turns on opposite DNA strands. Post-irradiation repair of single-base lesions is routinely performed by base excision repair and a DNA strand break is involved as an intermediate. Simultaneous processing of lesions on opposite DNA strands may generate double-strand DNA breaks and enhance nonhomologous end joining, which frequently results in the formation of deletions. Recent studies support the possibility that the mechanism of base excision repair contributes to genome stability by diminishing the formation of double-strand DNA breaks during processing of clustered lesions. |
| first_indexed | 2024-03-06T23:59:10Z |
| format | Journal article |
| id | oxford-uuid:7552e3b2-8e9c-4db9-9ddd-c3fc37be5c63 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:59:10Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:7552e3b2-8e9c-4db9-9ddd-c3fc37be5c632022-03-26T20:08:38ZSecuring genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7552e3b2-8e9c-4db9-9ddd-c3fc37be5c63EnglishSymplectic Elements at Oxford2001Dianov, GO'Neill, PGoodhead, DIn addition to double- and single-strand DNA breaks and isolated base modifications, ionizing radiation induces clustered DNA damage, which contains two or more lesions closely spaced within about two helical turns on opposite DNA strands. Post-irradiation repair of single-base lesions is routinely performed by base excision repair and a DNA strand break is involved as an intermediate. Simultaneous processing of lesions on opposite DNA strands may generate double-strand DNA breaks and enhance nonhomologous end joining, which frequently results in the formation of deletions. Recent studies support the possibility that the mechanism of base excision repair contributes to genome stability by diminishing the formation of double-strand DNA breaks during processing of clustered lesions. |
| spellingShingle | Dianov, G O'Neill, P Goodhead, D Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA. |
| title | Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA. |
| title_full | Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA. |
| title_fullStr | Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA. |
| title_full_unstemmed | Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA. |
| title_short | Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA. |
| title_sort | securing genome stability by orchestrating dna repair removal of radiation induced clustered lesions in dna |
| work_keys_str_mv | AT dianovg securinggenomestabilitybyorchestratingdnarepairremovalofradiationinducedclusteredlesionsindna AT oneillp securinggenomestabilitybyorchestratingdnarepairremovalofradiationinducedclusteredlesionsindna AT goodheadd securinggenomestabilitybyorchestratingdnarepairremovalofradiationinducedclusteredlesionsindna |