The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.

Hematopoietic stem cell (HSC) development is regulated by several signaling pathways and a number of key transcription factors, which include Scl/Tal1, Runx1, and members of the Smad family. However, it remains unclear how these various determinants interact. Using a genome-wide computational screen...

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Bibliographic Details
Main Authors: Pimanda, J, Donaldson, I, de Bruijn, M, Kinston, S, Knezevic, K, Huckle, L, Piltz, S, Landry, JR, Green, A, Tannahill, D, Göttgens, B
Format: Journal article
Language:English
Published: 2007