Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins.

AlphaB-Crystallin is a ubiquitous small heat-shock protein (sHsp) renowned for its chaperone ability to prevent target protein aggregation. It is stress-inducible and its up-regulation is associated with a number of disorders, including those linked to the deposition of misfolded proteins, such as A...

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Bibliographic Details
Main Authors: Meehan, S, Knowles, T, Baldwin, A, Smith, J, Squires, A, Clements, P, Treweek, T, Ecroyd, H, Tartaglia, G, Vendruscolo, M, Macphee, C, Dobson, C, Carver, J
Format: Journal article
Language:English
Published: 2007