MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic pathways and cause poor-prognosis leukemias. Here, we find tha...

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Bibliographic Details
Main Authors: Kerry, J, Godfrey, L, Repapi, E, Tapia, M, Blackledge, N, Ma, H, Ballabio, E, O'Byrne, S, Ponthan, F, Heidenreich, O, Roy, A, Roberts, I, Konopleva, M, Klose, R, Geng, H, Milne, T
Format: Journal article
Language:English
Published: Cell Press 2017

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