MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic pathways and cause poor-prognosis leukemias. Here, we find tha...

Descrición completa

Detalles Bibliográficos
Main Authors: Kerry, J, Godfrey, L, Repapi, E, Tapia, M, Blackledge, N, Ma, H, Ballabio, E, O'Byrne, S, Ponthan, F, Heidenreich, O, Roy, A, Roberts, I, Konopleva, M, Klose, R, Geng, H, Milne, T
Formato: Journal article
Idioma:English
Publicado: Cell Press 2017

Títulos similares

Títulos similares