Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

Eitemau Tebyg

• Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.
  gan: Pelosi, M, et al.
  Cyhoeddwyd: (1999)
• Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.
  gan: Visco, C, et al.
  Cyhoeddwyd: (2000)
• Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.
  gan: Di Bartolo, V, et al.
  Cyhoeddwyd: (2002)
• Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
  gan: Mège, D, et al.
  Cyhoeddwyd: (1996)
• Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.
  gan: Magistrelli, G, et al.
  Cyhoeddwyd: (1999)