Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.

Following T cell antigen receptor (TCR) engagement, the protein tyrosine kinase (PTK) ZAP-70 is rapidly phosphorylated on several tyrosine residues, presumably by two mechanisms: an autophosphorylation and a trans-phosphorylation by the Src-family PTK Lck. These events have been implicated in both p...

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Bibliographic Details
Main Authors: Di Bartolo, V, Mège, D, Germain, V, Pelosi, M, Dufour, E, Michel, F, Magistrelli, G, Isacchi, A, Acuto, O
Format: Journal article
Language:English
Published: 1999

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