Comparison of a batch and flow approach for the lipase-catalyzed resolution of a Cyclopropanecarboxylate ester, a key building block for the synthesis of ticagrelor
In this study a batch reactor process is compared to a flow chemistry approach for lipase-catalyzed resolution of the cyclopropanecarboxylate ester (±)-3. (1R,2R)-3 is a precursor of the amine (1R,2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the bioca...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Published: |
American Chemical Society
2016
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