Comparison of a batch and flow approach for the lipase-catalyzed resolution of a Cyclopropanecarboxylate ester, a key building block for the synthesis of ticagrelor
In this study a batch reactor process is compared to a flow chemistry approach for lipase-catalyzed resolution of the cyclopropanecarboxylate ester (±)-3. (1R,2R)-3 is a precursor of the amine (1R,2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the bioca...
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Bibliographic Details
| Main Authors: |
Hugentobler, K,
Rasparini, M,
Thompson, L,
Jolley, K,
Blacker, A,
Turner, N |
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| Format: | Journal article
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| Published: |
American Chemical Society
2016
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