Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model

Concerns about malaria parasite resistance to treatment with artemisinin drugs (ARTs) have grown with findings of prolonged parasite clearance t1/2s (>5 h) and their association with mutations in Plasmodium falciparum Kelch-propeller protein K13. Here, we describe a P. falciparum laboratory cross...

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Main Authors:	Sá, JM, Kaslow, SR, Krause, MA, Melendez-Muniz, VA, Salzman, RE, Kite, WA, Zhang, M, Moraes Barros, RR, Mu, J, Han, PK, Mershon, JP, Figan, CE, Caleon, RL, Rahman, RS, Gibson, TJ, Amaratunga, C, Nishiguchi, EP, Breglio, KF, Engels, TM, Velmurugan, S, Ricklefs, S, Straimer, J, Gnädig, NF, Deng, B, Liu, A, Diouf, A, Miura, K, Tullo, GS, Eastman, RT, Chakravarty, S, James, ER, Udenze, K, Li, S, Sturdevant, DE, Gwadz, RW, Porcella, SF, Long, CA, Fidock, DA, Thomas, ML, Fay, MP, Sim, BKL, Hoffman, SL, Adams, JH, Fairhurst, RM, Su, X-Z, Wellems, TE
Format:	Journal article
Language:	English
Published:	National Academy of Sciences 2018

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model

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