Early stopping of randomized clinical trials for overt efficacy is problematic.
OBJECTIVE: To illustrate controversial issues associated with stopping randomized controlled trials (RCTs) early for apparent benefit. STUDY DESIGN AND SETTING: The article presents our review of prior relevant work and our research group's reflections on early stopping. RESULTS: Compelling evi...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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