Exploring metabolic vulnerability and therapeutic potential in cancers with isocitrate dehydrogenase mutations
<p>Treatment of mutant isocitrate dehydrogenase 1 (IDH1) glioma remains challenging; targeted allosteric inhibitors currently provide limited clinical effect. Resistance to mutIDH1 inhibitors has also emerged in other cancers with mutant <em>IDH1</em>. IDH1 catalyses the decarboxyl...
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| Format: | Thesis |
| Language: | Englihs |
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2022
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