DNA double-strand break repair pathways, chromosomal rearrangements and cancer.
Chromosomal rearrangements, which can lead to oncogene activation and tumour suppressor loss, are a hallmark of cancer cells. Such outcomes can result from both the repair and misrepair of DNA ends, which arise from a variety of lesions including DNA double strand breaks (DSBs), collapsed replicatio...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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