Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Show other versions (1)

BACKGROUND: Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish t...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Zhou, K, Donnelly, L, Yang, J, Li, M, Deshmukh, H, Van Zuydam, N, Ahlqvist, E, Spencer, C, Groop, L, Morris, A, Colhoun, H, Sham, P, McCarthy, M, Palmer, C, Pearson, E
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2014

Eitemau Tebyg

Heritability of variation in glycaemic response to metformin: A genome-wide complex trait analysis
gan: Zhou, K, et al.
Cyhoeddwyd: (2014)

Estimating heritability of glycaemic response to metformin using nationwide electronic health records and population-sized pedigree
gan: Iris N. Kalka, et al.
Cyhoeddwyd: (2021-12-01)

Variation in the glucose transporter gene SLC2A2 is associated with glycaemic response to metformin
gan: Kaixin, Z, et al.
Cyhoeddwyd: (2016)

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with Type 2 diabetes: A Go-DARTS study
gan: Donnelly, L, et al.
Cyhoeddwyd: (2011)

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.
gan: Donnelly, L, et al.
Cyhoeddwyd: (2011)

Genome-wide association study of peripheral artery disease
gan: van Zuydam, NR, et al.
Cyhoeddwyd: (2021)

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.
gan: Zhou, K, et al.
Cyhoeddwyd: (2009)

The role of ATM in response to metformin treatment and activation of AMPK.
gan: Zhou, K, et al.
Cyhoeddwyd: (2012)

Towards a Region-Wide Glycaemic Management System: Strategies and Applications for Glycaemic Management of Patients with Diabetes During Hospitalisation
gan: He M, et al.
Cyhoeddwyd: (2024-09-01)

Metformin Pharmacogenetics and SLC2A2: Genome-Wide Association Study and 2-stage replication in GoDARTS and UKPDS
gan: Zhou, K, et al.
Cyhoeddwyd: (2013)

Massively expedited genome-wide heritability analysis (MEGHA)
gan: Ge, Tian, et al.
Cyhoeddwyd: (2015)

Pharmacogenetics in Type 2 diabetes: variation in TCF7L2 influences response to sulphonylureas
gan: Pearson, E, et al.
Cyhoeddwyd: (2007)

Large-scale genome-wide association meta-analysis of the 1000 genomes project imputed data identifies novel susceptibility loci for glycaemic and obesity traits
gan: Horikoshi, M, et al.
Cyhoeddwyd: (2013)

The Genetic Landscape of Renal Complications in Type 1 Diabetes
gan: Sandholm, N, et al.
Cyhoeddwyd: (2016)

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of two Dutch and two UK cohorts
gan: 't Hart, L, et al.
Cyhoeddwyd: (2011)

Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes
gan: Tanja Dujic, et al.
Cyhoeddwyd: (2019-11-01)

Dietary glycaemic index and glycaemic load in the European Prospective Investigation into Cancer and Nutrition.
gan: Bakel, v, et al.
Cyhoeddwyd: (2009)

Glycaemic Control after Metformin Discontinuation in Diabetic Patients with a Declining Renal Function
gan: Theresa Leyco, et al.
Cyhoeddwyd: (2017-01-01)

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts
gan: van Leeuwen, N, et al.
Cyhoeddwyd: (2012)

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.
gan: van Leeuwen, N, et al.
Cyhoeddwyd: (2012)

Heritability in the genome-wide association era
gan: Zaitlen, Noah, et al.
Cyhoeddwyd: (2017)

Gene expression profiling in skeletal muscle of subjects with different glycaemic tolerance.
gan: Lindgren, C, et al.
Cyhoeddwyd: (2001)

Glycaemic index and glycaemic load values of commonly consumed foods in the United Arab Emirates.
gan: Al Dhaheri, A, et al.
Cyhoeddwyd: (2017)

Role of Metformin Monotherapy Vs Metformin Plus Dapagliflozin in New Onset T2DM Among 40 Plus Obese Women in Glycaemic Control
gan: Amarjeet Singh, et al.
Cyhoeddwyd: (2024-10-01)

Finding the missing heritability of complex diseases.
gan: Manolio, T, et al.
Cyhoeddwyd: (2009)

Phenome-wide heritability analysis of the UK Biobank
gan: Ge, Tian, et al.
Cyhoeddwyd: (2017)

Phenome-wide heritability analysis of the UK Biobank.
gan: Tian Ge, et al.
Cyhoeddwyd: (2017-04-01)

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
gan: Pearson, E, et al.
Cyhoeddwyd: (2007)

Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
gan: Keller, M, et al.
Cyhoeddwyd: (2012)

Risk of anaemia with long-term metformin use in a community setting
gan: Donnelly, L, et al.
Cyhoeddwyd: (2017)

A Genome-wide Association Study Provides Evidence of Sex-specific Involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) With Diabetic Neuropathic Pain
gan: Weihua Meng, et al.
Cyhoeddwyd: (2015-10-01)

Correction: Phenome-wide heritability analysis of the UK Biobank.
gan: Tian Ge, et al.
Cyhoeddwyd: (2018-02-01)

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria
gan: Ahluwalia, T, et al.
Cyhoeddwyd: (2018)

Genome-wide associations for birth weight and correlations with adult disease
gan: Horikoshi, M, et al.
Cyhoeddwyd: (2016)

Glycaemic index and glycaemic load of foods and food products in Malaysia: a review
gan: Osman, M. H., et al.
Cyhoeddwyd: (2021)

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
gan: Hagenbeek, F, et al.
Cyhoeddwyd: (2020)

Identification of biomarkers for glycaemic deterioration in type 2 diabetes
gan: Slieker, Roderick C., et al.
Cyhoeddwyd: (2023)

Identification of biomarkers for glycaemic deterioration in type 2 diabetes
gan: Roderick C. Slieker, et al.
Cyhoeddwyd: (2023-05-01)

The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control
gan: F. Casanova, et al.
Cyhoeddwyd: (2017-09-01)

Effect of glycaemic control and the introduction of insulin therapy on retinopathy in non-insulin-dependent diabetes mellitus [2] (multiple letters)
gan: Stratton, I, et al.
Cyhoeddwyd: (1997)