Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin A, was identified as a hit against Wolbachia. Thi...

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Main Authors:	Taylor, MJ, von Geldern, TW, Ford, L, Hübner, MP, Marsh, K, Johnston, KL, Sjoberg, HT, Specht, S, Pionnier, N, Tyrer, HE, Clare, RH, Cook, DAN, Murphy, E, Steven, A, Archer, J, Bloemker, D, Lenz, F, Koschel, M, Ehrens, A, Metuge, HM, Chunda, VC, Chounna, PW, Njouendou, AJ, Fombad, FF, Carr, R, Morton, HE, Aljayyoussi, G, Hoerauf, A, Wanji, S, Kempf, DJ, Turner, JD, Ward, SA
格式:	Journal article
語言:	English
出版:	American Association for the Advancement of Science 2019

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

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