Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia

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Genetic lesions such as BCR-ABL1, E2A-PBX1, and MLL rearrangements (MLLr) are associated with unfavorable outcomes in adult B-cell precursor acute lymphoblastic leukemia (B-ALL). Leukemia oncoproteins may directly or indirectly disrupt cytosine methylation patterning to mediate the malignant phenoty...

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Bibliographic Details
Main Authors: Geng, H, Brennan, S, Milne, T, Chen, W, Li, Y, Hurtz, C, Kweon, S, Zickl, L, Shojaee, S, Neuberg, D, Huang, C, Biswas, D, Xin, Y, Racevskis, J, Ketterling, R, Luger, S, Lazarus, H, Tallman, MS, Rowe, J, Litzow, MR, Guzman, M, David Allis, C, Roeder, R, Müschen, M, Paietta, E
Format: Journal article
Language:English
Published: 2012

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