Too weak for biophysics: Prioritising and progressing fragment hits from X-ray crystallographic screening.

<p>In the last decade, X-ray crystallography has matured to a powerful primary screening technique for fragment hit identification in structure-based drug discovery. Unmatched in its sensitivity, it provides valuable knowledge of precise fragment binding location in a protein-fragment complex....

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Bibliographic Details
Main Author: Dubianok, Y
Other Authors: von Delft, F
Format: Thesis
Language:English
Published: 2021
Subjects: