Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.

BACKGROUND: The 26S proteasome is responsible for most cytosolic proteolysis, and is an important protease in major histocompatibility complex class I-mediated antigen presentation. Constitutively expressed proteasomes from mammalian sources possess three distinct catalytically active species, beta1...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Kessler, B, Tortorella, D, Altun, M, Kisselev, A, Fiebiger, E, Hekking, BG, Ploegh, H, Overkleeft, H
Format: Journal article
Sprache:English
Veröffentlicht: 2001

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