A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome.

The mobilization of triacylglycerides from storage in adipocytes to the liver is a vital response to the fasting state in mammalian metabolism. This is accompanied by a rapid translational activation of genes encoding mitochondrial, microsomal, and peroxisomal beta-oxidation in the liver, in part un...

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Bibliographic Details
Main Authors: Atherton, H, Bailey, N, Zhang, W, Taylor, J, Major, H, Shockcor, J, Clarke, K, Griffin, J
Format: Journal article
Language:English
Published: 2006