Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.

Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia. To better understand this transcriptional cascade we performed genome-wide chromatin immunoprecipitation using antibodies to two major HIF-alpha subunits, and correlated the results with genome-wide transcri...

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Bibliographic Details
Main Authors: Mole, D, Blancher, C, Copley, R, Pollard, P, Gleadle, J, Ragoussis, J, Ratcliffe, P
Format: Journal article
Language:English
Published: 2009