Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

Frontotemporal dementia (FTD)-causing mutations in the CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B. We report that transgenic mice expressing endogenous levels of mutant CHMP2B developed late-onset brain volume loss associated with frank neuronal loss and FTD-like chan...

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Bibliographic Details
Main Authors:	Clayton, E, Mancuso, R, Nielsen, T, Mizielinska, S, Holmes, H, Powell, N, Norona, F, Overgaard Larsen, J, Milioto, C, Wilson, K, Lythgoe, M, Ourselin, S, Nielsen, J, Johannsen, P, Holm, I, Collinge, J, Frej, A, Oliver, P, Gomez-Nicola, D, Isaacs, A
Format:	Journal article
Language:	English
Published:	Oxford University Press 2017

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

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