Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.
A locus for Peutz-Jeghers syndrome (PJS) was recently mapped to chromosome 19p13.3. Each of 12 families studied was compatible with linkage to the marker D19S886. We have analysed 20 further families and found that the majority of these are consistent with a PJS gene on 19p13.3. Three families were,...
| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
1998
|
| _version_ | 1826279731584040960 |
|---|---|
| author | Olschwang, S Markie, D Seal, S Neale, K Phillips, R Cottrell, S Ellis, I Hodgson, S Zauber, P Spigelman, A Iwama, T Loff, S McKeown, C Marchese, C Sampson, J Davies, S Talbot, I Wyke, J Thomas, G Bodmer, W Hemminki, A Avizienyte, E de la Chapelle, A Aaltonen, L Tomlinson, I |
| author_facet | Olschwang, S Markie, D Seal, S Neale, K Phillips, R Cottrell, S Ellis, I Hodgson, S Zauber, P Spigelman, A Iwama, T Loff, S McKeown, C Marchese, C Sampson, J Davies, S Talbot, I Wyke, J Thomas, G Bodmer, W Hemminki, A Avizienyte, E de la Chapelle, A Aaltonen, L Tomlinson, I |
| author_sort | Olschwang, S |
| collection | OXFORD |
| description | A locus for Peutz-Jeghers syndrome (PJS) was recently mapped to chromosome 19p13.3. Each of 12 families studied was compatible with linkage to the marker D19S886. We have analysed 20 further families and found that the majority of these are consistent with a PJS gene on 19p13.3. Three families were, however, unlinked to 19p13.3 and none of the available PJS polyps from these families showed allele loss at D19S886. There were no obvious clinicopathological or ethnic differences between the 19p13.3 linked and unlinked families. There appears, therefore, to be a major PJS locus on chromosome 19p13.3 and the possibility exists of a minor locus (or loci) elsewhere. |
| first_indexed | 2024-03-07T00:03:10Z |
| format | Journal article |
| id | oxford-uuid:76a969cb-590c-48d6-bf0a-091f30883a83 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:03:10Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:76a969cb-590c-48d6-bf0a-091f30883a832022-03-26T20:17:51ZPeutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:76a969cb-590c-48d6-bf0a-091f30883a83EnglishSymplectic Elements at Oxford1998Olschwang, SMarkie, DSeal, SNeale, KPhillips, RCottrell, SEllis, IHodgson, SZauber, PSpigelman, AIwama, TLoff, SMcKeown, CMarchese, CSampson, JDavies, STalbot, IWyke, JThomas, GBodmer, WHemminki, AAvizienyte, Ede la Chapelle, AAaltonen, LTomlinson, IA locus for Peutz-Jeghers syndrome (PJS) was recently mapped to chromosome 19p13.3. Each of 12 families studied was compatible with linkage to the marker D19S886. We have analysed 20 further families and found that the majority of these are consistent with a PJS gene on 19p13.3. Three families were, however, unlinked to 19p13.3 and none of the available PJS polyps from these families showed allele loss at D19S886. There were no obvious clinicopathological or ethnic differences between the 19p13.3 linked and unlinked families. There appears, therefore, to be a major PJS locus on chromosome 19p13.3 and the possibility exists of a minor locus (or loci) elsewhere. |
| spellingShingle | Olschwang, S Markie, D Seal, S Neale, K Phillips, R Cottrell, S Ellis, I Hodgson, S Zauber, P Spigelman, A Iwama, T Loff, S McKeown, C Marchese, C Sampson, J Davies, S Talbot, I Wyke, J Thomas, G Bodmer, W Hemminki, A Avizienyte, E de la Chapelle, A Aaltonen, L Tomlinson, I Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. |
| title | Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. |
| title_full | Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. |
| title_fullStr | Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. |
| title_full_unstemmed | Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. |
| title_short | Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. |
| title_sort | peutz jeghers disease most but not all families are compatible with linkage to 19p13 3 |
| work_keys_str_mv | AT olschwangs peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT markied peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT seals peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT nealek peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT phillipsr peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT cottrells peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT ellisi peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT hodgsons peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT zauberp peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT spigelmana peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT iwamat peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT loffs peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT mckeownc peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT marchesec peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT sampsonj peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT daviess peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT talboti peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT wykej peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT thomasg peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT bodmerw peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT hemminkia peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT avizienytee peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT delachapellea peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT aaltonenl peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 AT tomlinsoni peutzjeghersdiseasemostbutnotallfamiliesarecompatiblewithlinkageto19p133 |