Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines.
Wnt signaling pathway activation via mutation of genetic components, commonly adenomatous polyposis coli (APC), has a major role in colorectal cancer (CRC). Most components have not been assessed for mutation in sporadic CRC. We have analyzed AXIN2, CK1alpha, DKK1, GSK-3beta, SOX17, LRP6 and PPP2R1B...
Main Authors: | , , , , , , |
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Format: | Journal article |
Jezik: | English |
Izdano: |
2006
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