Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines.

Wnt signaling pathway activation via mutation of genetic components, commonly adenomatous polyposis coli (APC), has a major role in colorectal cancer (CRC). Most components have not been assessed for mutation in sporadic CRC. We have analyzed AXIN2, CK1alpha, DKK1, GSK-3beta, SOX17, LRP6 and PPP2R1B...

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Bibliografske podrobnosti
Main Authors: Suraweera, N, Robinson, J, Volikos, E, Guenther, T, Talbot, I, Tomlinson, I, Silver, A
Format: Journal article
Jezik:English
Izdano: 2006