Parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance.
Elevated proinsulin secretion and islet amyloid deposition are both features of Type 2 diabetes but their relationship to beta-cell dysfunction is unknown. To determine if islet amyloid polypeptide (IAPP) secretion is disproportionate with other beta-cell products at any stage of glucose intolerance...
| المؤلفون الرئيسيون: | , , , , , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2000
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| _version_ | 1826279783014596608 |
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| author | MacNamara, C Barrow, B Manley, SE Levy, J Clark, A Turner, R |
| author_facet | MacNamara, C Barrow, B Manley, SE Levy, J Clark, A Turner, R |
| author_sort | MacNamara, C |
| collection | OXFORD |
| description | Elevated proinsulin secretion and islet amyloid deposition are both features of Type 2 diabetes but their relationship to beta-cell dysfunction is unknown. To determine if islet amyloid polypeptide (IAPP) secretion is disproportionate with other beta-cell products at any stage of glucose intolerance, 116 subjects were studied. Non-diabetic subjects with equivalent body mass index (BMI) were assigned to three groups, (i) normal fasting glucose, fpg<5.5 mmol l(-1); (ii) intermediate fasting glucose, fpg> or =5.5<6.15 mmol l(-1); (iii) impaired fasting glucose (IFG), fpg> or =6.1<7.0 mmol l(-1). Diabetic subjects were divided according to therapy (9 diet, 19 tablet, and 11 insulin). IAPP, C-peptide and proinsulin were measured fasting and at the end of a 1-h glucose infusion. Fasting C-peptide, IAPP and proinsulin were significantly elevated in the IFG group compared with the other non-diabetic groups (P<0.02); fasting IAPP/C-peptide and proinsulin/C-peptide were 1-2% in all non-diabetic groups. Fasting and 1-h proinsulin and proinsulin/C-peptide were higher in diabetic compared with non-diabetic subjects (P<0.01). IAPP and IAPP/C-peptide in diabetic groups were similar to that in non-diabetic subjects but reduced in the insulin-treated group (P<0.01). Proinsulin was disproportionately increased compared with C-peptide and IAPP in Type 2 diabetes particularly in severe beta-cell failure implying more than one concurrent beta-cell pathology. |
| first_indexed | 2024-03-07T00:03:56Z |
| format | Journal article |
| id | oxford-uuid:76e8ecae-783e-485e-a6a7-e66fd8c813f5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:03:56Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:76e8ecae-783e-485e-a6a7-e66fd8c813f52022-03-26T20:19:35ZParallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:76e8ecae-783e-485e-a6a7-e66fd8c813f5EnglishSymplectic Elements at Oxford2000MacNamara, CBarrow, BManley, SELevy, JClark, ATurner, RElevated proinsulin secretion and islet amyloid deposition are both features of Type 2 diabetes but their relationship to beta-cell dysfunction is unknown. To determine if islet amyloid polypeptide (IAPP) secretion is disproportionate with other beta-cell products at any stage of glucose intolerance, 116 subjects were studied. Non-diabetic subjects with equivalent body mass index (BMI) were assigned to three groups, (i) normal fasting glucose, fpg<5.5 mmol l(-1); (ii) intermediate fasting glucose, fpg> or =5.5<6.15 mmol l(-1); (iii) impaired fasting glucose (IFG), fpg> or =6.1<7.0 mmol l(-1). Diabetic subjects were divided according to therapy (9 diet, 19 tablet, and 11 insulin). IAPP, C-peptide and proinsulin were measured fasting and at the end of a 1-h glucose infusion. Fasting C-peptide, IAPP and proinsulin were significantly elevated in the IFG group compared with the other non-diabetic groups (P<0.02); fasting IAPP/C-peptide and proinsulin/C-peptide were 1-2% in all non-diabetic groups. Fasting and 1-h proinsulin and proinsulin/C-peptide were higher in diabetic compared with non-diabetic subjects (P<0.01). IAPP and IAPP/C-peptide in diabetic groups were similar to that in non-diabetic subjects but reduced in the insulin-treated group (P<0.01). Proinsulin was disproportionately increased compared with C-peptide and IAPP in Type 2 diabetes particularly in severe beta-cell failure implying more than one concurrent beta-cell pathology. |
| spellingShingle | MacNamara, C Barrow, B Manley, SE Levy, J Clark, A Turner, R Parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance. |
| title | Parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance. |
| title_full | Parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance. |
| title_fullStr | Parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance. |
| title_full_unstemmed | Parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance. |
| title_short | Parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance. |
| title_sort | parallel changes of proinsulin and islet amyloid polypeptide in glucose intolerance |
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