The effect of tetracyclines on quantitative measures of osteoclast morphology.

We report the effects of the tetracycline analogues 4-dedimethylaminotetracycline (CMT-1) and minocycline on osteoclast spreading and motility. Both agents influenced the morphometric descriptor of cell spread area, rho, producing cellular retraction or an R effect (half-times: 30 and 44 minutes for...

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Bibliographic Details
Main Authors: Zaidi, M, Moonga, B, Huang, C, Towhidul Alam, A, Shankar, V, Pazianas, M, Eastwood, J, Datta, H, Rifkin, B
Format: Journal article
Language:English
Published: Kluwer Academic Publishers-Plenum Publishers 1993