Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

Hereditary mixed polyposis syndrome (HMPS) is characterized by apparent autosomal dominant inheritance of multiple types of colorectal polyp, with colorectal carcinoma occurring in a high proportion of affected individuals. Here, we use genetic mapping, copy-number analysis, exclusion of mutations b...

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Bibliografiska uppgifter
Huvudupphovsmän:	Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I
Materialtyp:	Journal article
Språk:	English
Publicerad:	2012

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

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