Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.

AIMS: The Type 1 diabetes susceptibility locus, IDDM2, has been mapped to a variable number of tandem repeats (VNTR) region 5' upstream of the insulin (INS) and insulin-like growth factor (IGF2) genes on chromosome 11p15. The function of the VNTR is uncertain; however, it may influence the thym...

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Bibliographic Details
Main Authors: Tait, K, Collins, J, Heward, J, Eaves, I, Snook, H, Franklyn, J, Barnett, A, Todd, J, Maranian, M, Compston, A, Sawcer, S, Gough, S
Format: Journal article
Language:English
Published: 2004