Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents

Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents

Manylion Llyfryddiaeth
Prif Awduron:	Hulley, P, Horsch, K, De Wet, H, Conradie, M, Langeveldt, C, Hough, F
Fformat:	Conference item
Cyhoeddwyd:	2003

Eitemau Tebyg

Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
gan: Horsch, K, et al.
Cyhoeddwyd: (2004)

Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
gan: Horsch, K, et al.
Cyhoeddwyd: (2004)

Vanadate protects osteoblasts in vitro and in vivo from glucocorticoid impairment of proliferation
gan: Hulley, P, et al.
Cyhoeddwyd: (2002)

MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.
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Cyhoeddwyd: (2011)

Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.
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Cyhoeddwyd: (2003)

Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.
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Cyhoeddwyd: (2007)

The Role of MKP-1 in the Anti-Proliferative Effects of Glucocorticoids in Primary Rat Pre-Osteoblasts.
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Glucocorticoid-induced osteoporosis in the rat is prevented by the tyrosine phosphatase inhibitor, sodium orthovanadate.
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Cyhoeddwyd: (2002)

Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation.
gan: Horsch, K, et al.
Cyhoeddwyd: (2007)

The tyrosine phosphatase inhibitor vanadate protects osteoblasts from growth inhibition by glucocorticoids.
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Cyhoeddwyd: (1999)

Alternative insulin signalling pathways in osteoblasts
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Cyhoeddwyd: (2002)

Alternative insulin signalling pathways in osteoblast cell lines
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Cyhoeddwyd: (2002)

Pharmacological estrogen administration causes a FSH-independent osteo-anabolic effect requiring ER alpha in osteoblasts.
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Cyhoeddwyd: (2012-01-01)

Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast
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Cyhoeddwyd: (2020-01-01)

The identification of transcriptional targets associated with osteoblast apoptosis signaling in response to growth factor withdrawal
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Cyhoeddwyd: (2006)

Corrigendum: Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast
Cyhoeddwyd: (2021-01-01)

Regulation of bim in glucocorticoid-mediated osteoblast apoptosis.
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Cyhoeddwyd: (2008)

Pathogenesis of glucocorticoid osteoporosis: Role of tyrosine phosphatases
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Cyhoeddwyd: (2001)

The BH3-only protein BIM is upregulated in osteoblasts in response to dexamethasone treatment, growth factor deprivation and anoikis
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Cyhoeddwyd: (2005)

BIM is a novel regulator of glucocorticoid-induced apoptosis in osteoblasts
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Cyhoeddwyd: (2006)

Inhibition of mitogen-activated protein kinase activity and proliferation of an early osteoblast cell line (MBA 15.4) by dexamethasone: role of protein phosphatases.
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Cyhoeddwyd: (1998)

Bim as a potential target in osteoblast survival
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OsteoBLAST: Computational Routine of Global Molecular Analysis Applied to Biomaterials Development
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Cynarin attenuates LPS-induced endothelial inflammation via upregulation of the negative regulator MKP-3
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Cyhoeddwyd: (2022-05-01)

Regulation of the CCL2 gene in pancreatic β-cells by IL-1β and glucocorticoids: role of MKP-1.
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Identification of polymorphisms in the MKP1 gene and their association with bone mineral density in men with asthma
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Cyhoeddwyd: (2005)

Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation
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Cyhoeddwyd: (2024-12-01)

Stattns: Potential cartilage anabolics?
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Cyhoeddwyd: (2004)

Anabolic effects and inhibition of interleukin 6 production induced by neridronate on human osteoblasts
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Cyhoeddwyd: (2011-09-01)

Randomness improvement of AES using MKP
gan: Al-Alak, Saif, et al.
Cyhoeddwyd: (2013)

Nonlinearity contributions on critical MKP equation
gan: H.G. Abdelwahed
Cyhoeddwyd: (2020-01-01)

MECHANISMS OF OSTEOBLAST INHIBITION BY STEROIDS
gan: Hulley, P
Cyhoeddwyd: (2004)

Bim is transcriptionally regulated during induction of apoptosis by growth factor withdrawal in osteoblasts
gan: Liang, M, et al.
Cyhoeddwyd: (2007)

Comparison of the Anabolic Effects of Reported Osteogenic Compounds on Human Mesenchymal Progenitor-derived Osteoblasts
gan: Robert Owen, et al.
Cyhoeddwyd: (2020-01-01)

Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway.
gan: Bo Gao, et al.
Cyhoeddwyd: (2014-01-01)

OsteoKnee®
gan: Lai, K.W.
Cyhoeddwyd: (2015)

Role and regulation of MKP-1 in airway inflammation
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Cyhoeddwyd: (2017-08-01)

The Unexpected Anabolic Phenotype and Extended Longevity of Skin Fibroblasts after Chronic Glucocorticoid Excess
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Cyhoeddwyd: (2006-04-01)

Prenatal dexamethasone exposure reduces osteoprogenitor proliferation in mice via histone modifications at the Mkp-1 gene locus
gan: Yongheng Xie, et al.
Cyhoeddwyd: (2024-11-01)

TBX3 regulates the transcription of VEGFA to promote osteoblasts proliferation and microvascular regeneration
gan: Lichuang Wu, et al.
Cyhoeddwyd: (2022-07-01)