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Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents

Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents

Detalles Bibliográficos
Main Authors: Hulley, P, Horsch, K, De Wet, H, Conradie, M, Langeveldt, C, Hough, F
Formato: Conference item
Publicado: 2003
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  • Vanadate protects osteoblasts in vitro and in vivo from glucocorticoid impairment of proliferation
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  • Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.
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