Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.

Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape. We analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL epitope and found...

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Bibliografische gegevens
Hoofdauteurs: Iversen, A, Stewart-Jones, G, Learn, G, Christie, N, Sylvester-Hviid, C, Armitage, A, Kaul, R, Beattie, T, Lee, J, Li, Y, Chotiyarnwong, P, Dong, T, Xu, X, Luscher, M, MacDonald, K, Ullum, H, Klarlund-Pedersen, B, Skinhøj, P, Fugger, L, Buus, S, Mullins, J, Jones, E, Van Der Merwe, P, Mcmichael, A
Formaat: Journal article
Taal:English
Gepubliceerd in: 2006

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