Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.

Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape. We analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL epitope and found...

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Bibliographic Details
Main Authors:	Iversen, A, Stewart-Jones, G, Learn, G, Christie, N, Sylvester-Hviid, C, Armitage, A, Kaul, R, Beattie, T, Lee, J, Li, Y, Chotiyarnwong, P, Dong, T, Xu, X, Luscher, M, MacDonald, K, Ullum, H, Klarlund-Pedersen, B, Skinhøj, P, Fugger, L, Buus, S, Mullins, J, Jones, E, Van Der Merwe, P, Mcmichael, A
Format:	Journal article
Language:	English
Published:	2006

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.

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