Heterogeneous leukemia stem cells in myeloid blast phase chronic myeloid leukemia

Chronic myeloid leukemia (CML) is an excellent model of the multistep processes in cancer. Initiating BCR-ABL mutations are required for the initial phase of the disease (chronic phase, CP-CML). Some CP-CML patients acquire additional mutation(s) that transforms CP-CML to poor prognosis, hard to tre...

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Bibliographic Details
Main Authors: Kinstrie, R, Karamitros, D, Goardon, N, Morrison, H, Hamblin, M, Robinson, L, Clark, R, Copland, M, Vyas, P
Format: Journal article
Language:English
Published: American Society of Hematology 2016