Defective B cell development and function in Btk-deficient mice.

Mutations in the Bruton's tyrosine kinase (Btk) gene have been linked to severe early B cell developmental blocks in human X-linked agammaglobulinemia (XLA), and to milder B cell activation deficiencies in murine X-linked immune deficiency (Xid). To elucidate unequivocally potential Btk functio...

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Bibliographic Details
Main Authors: Khan, W, Alt, F, Gerstein, R, Malynn, B, Larsson, I, Rathbun, G, Davidson, L, Müller, S, Kantor, AB, Herzenberg, L
Format: Journal article
Language:English
Published: 1995