Defective B cell development and function in Btk-deficient mice.
Mutations in the Bruton's tyrosine kinase (Btk) gene have been linked to severe early B cell developmental blocks in human X-linked agammaglobulinemia (XLA), and to milder B cell activation deficiencies in murine X-linked immune deficiency (Xid). To elucidate unequivocally potential Btk functio...
Main Authors: | , , , , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
1995
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