Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation

Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation

O-GlcNAcylation is a newly discovered histone modification implicated in transcriptional regulation, but no structural information on the physical effect of GlcNAcylation on chromatin exists. Here, we generate synthetic, pure GlcNAcylated histones and nucleosomes and reveal that GlcNAcylation can mo...

Полное описание

Библиографические подробности
Главные авторы:	Lercher, L, Raj, R, Patel, N, Price, J, Mohammed, S, Robinson, C, Schofield, C, Davis, B
Формат:	Journal article
Язык:	English
Опубликовано:	Nature Publishing Group 2015

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