Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeric “RCR-complex”. We investigate whether RCR-complex vaccina...

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Opis bibliograficzny
Główni autorzy: Williams, BG, King, LDW, Pulido, D, Quinkert, D, Lias, AM, Silk, SE, Ragotte, RJ, Davies, H, Barrett, JR, McHugh, K, Rigby, CA, Alanine, DGW, Barfod, L, Shea, MW, Cowley, LA, Dabbs, RA, Pattinson, DJ, Douglas, AD, Lyth, OR, Illingworth, JJ, Jin, J, Carnrot, C, Kotraiah, V, Christen, JM, Skinner, K, Higgins, MK, Draper, SJ
Format: Journal article
Język:English
Wydane: Nature Research 2024

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