Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the degradation of selected proteins, potentially including otherwise 'undruggabl...

Full description

Bibliographic Details
Main Authors:	Turnbull, AP, Ioannidis, S, Krajewski, WW, Pinto-Fernandez, A, Heride, C, Martin, ACL, Tonkin, LM, Townsend, EC, Buker, SM, Lancia, DR, Caravella, JA, Toms, AV, Charlton, TM, Lahdenranta, J, Wilker, E, Follows, BC, Evans, NJ, Stead, L, Alli, C, Zarayskiy, VV, Talbot, AC, Buckmelter, AJ, Wang, M, McKinnon, CL, Saab, F, McGouran, JF, Century, H, Gersch, M, Pittman, MS, Marshall, CG, Raynham, TM, Simcox, M, Stewart, LMD, McLoughlin, SB, Escobedo, JA, Bair, KW, Dinsmore, CJ, Hammonds, TR, Kim, S, Urbé, S, Clague, MJ, Kessler, BM, Komander, D
Format:	Journal article
Language:	English
Published:	Nature Publishing Group 2017

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Similar Items