Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro

The transcription factor p63 is expressed in many different isoforms as a result of differential promoter use and splicing. Some of these isoforms have very specific physiological functions in the development and maintenance of epithelial tissues and surveillance of genetic integrity in oocytes. The...

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Bibliographic Details
Main Authors: Lotz, R, Osterburg, C, Chaikuad, A, Weber, S, Akutsu, M, Machel, AC, Beyer, U, Gebel, J, Löhr, F, Knapp, S, Dobbelstein, M, Lu, X, Dötsch, V
Format: Journal article
Language:English
Published: Springer Nature [academic journals on nature.com] 2025