CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68.1.
The crystal structure of the HLA-Aw68.1 antigen binding site revealed a negatively charged pocket centred on aspartic acid 74 (Garrett et al. 1989). Access to this '74 pocket' is blocked in HLA-Aw68.2 and HLA-Aw69 by two substitutions at positions 97 and 116. This key feature suggests that...
| Main Authors: | , , , , |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
1991
|