Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice

Genome-wide association studies have linked polymorphisms in the autophagy gene ATG16L1 with susceptibility to inflammatory bowel disease (IBD). However, the cell-type-specific effects of autophagy on the regulation of chronic intestinal inflammation have not been investigated. Here, we assessed the...

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Bibliographic Details
Main Authors: Pott, J, Kabat, A, Maloy, K
Format: Journal article
Language:English
Published: Cell Press 2018