Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.
Gain-of-function mutations in the Cu,Zn-superoxide dismutase (SOD1) gene are implicated in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral sclerosis (ALS). At present, transgenic expression of 12 human SOD1 mutations driven by the endogenous promoter is dise...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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