A Fluorescence‐based assay for screening β‐lactams targeting the Mycobacterium tuberculosis transpeptidase LdtMt2

Mycobacterium tuberculosis L,D‐transpeptidases (Ldts), which are involved in cell wall biosynthesis, have emerged as promising targets for the treatment of tuberculosis. However, an efficient method for testing inhibition of these enzymes is not currently available. We present a fluorescence‐based a...

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Main Authors: De Munnik, M, Lohans, C, Langley, G, Bon, C, Brem, J, Schofield, C
格式: Journal article
语言:English
出版: Wiley 2019