Mitochondrial dysfunction and mitophagy in Parkinson’s disease: From mechanism to therapy

Mitochondrial dysfunction and mitophagy in Parkinson’s disease: From mechanism to therapy

Mitochondrial dysfunction is implicated in PD through both environmental exposure and genetic factors. Increased understanding of mitochondrial dysfunction and mitophagy in PD has identified new mechanisms and therapeutic opportunities. Identification of the up- and downstream regulators of PINK1/pa...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Malpartida, AB, Williamson, M, Narendra, DP, Wade-Martins, R, Ryan, BJ
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	Cell Press 2020

समान संसाधन

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.
द्वारा: Ryan, B, और अन्य
प्रकाशित: (2015)

Modulating mitophagy in mitochondrial disease.
द्वारा: Dombi, E, और अन्य
प्रकाशित: (2017)

Detecting mitophagy in mitochondrial disease: towards a new type of therapy
द्वारा: Dombi, E
प्रकाशित: (2019)

The role of astrocyte dysfunction in Parkinson's disease pathogenesis
द्वारा: Booth, H, और अन्य
प्रकाशित: (2017)

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
द्वारा: Smith, A, और अन्य
प्रकाशित: (2018)

Mitophagy plays a central role in mitochondrial ageing
द्वारा: Diot, A, और अन्य
प्रकाशित: (2016)

Mitochondrial dysfunction and Parkinson’s disease — near-infrared photobiomodulation as a potential therapeutic strategy
द्वारा: Foo, Aaron Song Chuan, और अन्य
प्रकाशित: (2021)

Targeting alpha-synuclein as a therapy for Parkinson’s disease
द्वारा: Fields, CR, और अन्य
प्रकाशित: (2019)

Oculomotor Dysfunction in Parkinson's Disease
द्वारा: Kennard, C, और अन्य
प्रकाशित: (2013)

Oculomotor Dysfunction in Parkinson's Disease
द्वारा: Kennard, C, और अन्य
प्रकाशित: (2013)

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.
द्वारा: Ryan, B, और अन्य
प्रकाशित: (2014)

Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy
द्वारा: Tan, Sijie, और अन्य
प्रकाशित: (2017)

Investigating the effects of autophagic perturbations on mitochondrial function in Parkinson’s Disease
द्वारा: Ryan Barlow Patterson
प्रकाशित: (2019)

The role of mitophagy during oocyte aging in human, mouse, and Drosophila: implications for oocyte quality and mitochondrial disease
द्वारा: Cox, RT, और अन्य
प्रकाशित: (2021)

Mitochondrial dysfunction in Down Syndrome: from pathology to therapy
द्वारा: Tan, Kai-Leng, और अन्य
प्रकाशित: (2023)

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations.
द्वारा: Liao, C, और अन्य
प्रकाशित: (2016)

Convergent pathways in Parkinson’s disease
द्वारा: Cherubini, M, और अन्य
प्रकाशित: (2017)

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
द्वारा: Ryan, B, और अन्य
प्रकाशित: (2014)

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models
द्वारा: Oh, Chang-Ki, और अन्य
प्रकाशित: (2018)

Dysregulated mitophagy and mitochondrial transport in severe dominant optic atrophy due to OPA1 mutations
द्वारा: Liao, C, और अन्य
प्रकाशित: (2012)

Dysregulated mitophagy and mitochondrial transport in severe inherited optic atrophy due to OPA1 mutations
द्वारा: Poulton, J, और अन्य
प्रकाशित: (2012)

Compounds from an Unbiased Chemical Screen Reverse Both Er-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models
द्वारा: Su, Linhui Julie, और अन्य
प्रकाशित: (2011)

The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy
द्वारा: Poulton, J, और अन्य
प्रकाशित: (2016)

Are rodent models of Parkinson's disease behaving as they should?
द्वारा: Vingill, S, और अन्य
प्रकाशित: (2017)

Restorative therapies in Parkinsons disease /
द्वारा: Brundin, Patrik, और अन्य
प्रकाशित: (2006)

Parkinson disease, LRRK2 and the endocytic-autophagic pathway.
द्वारा: Alegre-Abarrategui, J, और अन्य
प्रकाशित: (2009)

α-Synuclein and dopamine at the crossroads of Parkinson's disease.
द्वारा: Venda, L, और अन्य
प्रकाशित: (2010)

Cortical structural involvement and cognitive dysfunction in early Parkinson's disease
द्वारा: Klein, J, और अन्य
प्रकाशित: (2018)

Role of mitophagy in muscle growth and metabolism
द्वारा: Peker, Nesibe
प्रकाशित: (2017)

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons
द्वारा: Zambon, F, और अन्य
प्रकाशित: (2019)

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models
द्वारा: Fernandes, H, और अन्य
प्रकाशित: (2017)

Hypoxia as a therapy for mitochondrial disease
द्वारा: Jain, I. H., और अन्य
प्रकाशित: (2017)

Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease
द्वारा: Park, Jung Eun, और अन्य
प्रकाशित: (2019)

UNDERSTANDING THE EARLY PATHOLOGICAL PATHWAYS IN PARKINSON'S DISEASE. THE OXFORD PARKINSON'S DISEASE CENTRE
द्वारा: Hu, M, और अन्य
प्रकाशित: (2010)

Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer’s disease with cerebrovascular disease
द्वारा: Gallart-Palau, Xavier, और अन्य
प्रकाशित: (2018)

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.
द्वारा: Janezic, S, और अन्य
प्रकाशित: (2013)

Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and CSF
द्वारा: Winchester, L, और अन्य
प्रकाशित: (2022)

What is our understanding of the influence of gut microbiota on the pathophysiology of Parkinson’s disease?
द्वारा: Hill, A, और अन्य
प्रकाशित: (2021)

Oxygen, the invisible orchestrator of metabolism and disease : a focus on mitochondrial And peroxisomal dysfunction
द्वारा: Jain, Isha Himani
प्रकाशित: (2018)

Pathological features of mitochondrial respiratory chain dysfunction
द्वारा: Chen, Walter W
प्रकाशित: (2016)